Oct 14 2022An integrative 2D multiscale model of wound closure that links observations at the single cell and collective cell migration scales is developed and it is found that directionality plays a key role during wound closure and is inhibited by PIEZO1 activity The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for
Get PriceNov 4 2022The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for individual cellular locomotion and the coordination of movement across cells Leader cells along the wound edge transmit mechanical and biochemical cues to ensuing follower cells ensuring their coordinated direction of migration or directionality Despite the
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